Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

lipid nanoparticle encapsulating hAQP1 circular RNA RXRG001

A formulation consisting of lipid nanoparticles (LNPs) encapsulating circular RNA (circRNA) encoding human aquaporin-1 (hAQP1), with potential saliva enhancing activity. Upon intraductal administration of LNP encapsulating hAQP1 circRNA RXRG001 to parotid gland(s), the LNP binds to the plasma membrane and releases the circRNA into the cell. The circRNA is then translated to produce hAQP1, which restores water permeability of the cell and increases saliva production. This may alleviate dry mouth symptoms. hAQP1, a water channel protein, is one of several highly conserved water channel proteins that mediates water permeability in cells of water-transporting tissues.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:lipid nanoparticle encapsulating human aquaporin-1 circular RNA RXRG001
LNP encapsulating hAQP1 circRNA RXRG001
Code name:RXRG 001
RXRG-001
RXRG001
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search