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lutetium Lu 177 rsopatamab tetraxetan

A radioimmunoconjugate consisting of rosopatamab, a humanized monoclonal antibody (MoAb) against the external domain of the prostate-specific membrane antigen (PSMA) that is linked, via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during single-photon emission computerized tomography/computerized tomography (SPECT/CT). Upon administration, lutetium Lu 177 rosopatamab tetraxetan binds to PSMA expressed on certain tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to PSMA-expressing cells. PSMA is overexpressed in the malignant prostate and its metastases.
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Synonym:177Lu-DOTA-TLX591
DOTA-HUJ-591 LU-177
lutetium Lu 177 rosopatamab
lutetium Lu 177-DOTA-rosopatamab
lutetium Lu 177-DOTA-TLX591
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