mapatumumab
A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth.
| Synonym: | Anti-TRAIL R1-mAb |
|---|---|
| Abbreviation: | TRM-1 mAb |
| Code name: | HGS-ETR1 |