NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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medroxyprogesterone acetate
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:depot-medroxyprogestereone acetate
metipregnone
US brand name:Amen
Depo-Provera
Provera
Foreign brand name:Aragest
Ciclotal
Clinofem
Clinovir
Depo-Clinovir
Farlutal
Gestapuran
G-Farlutal
Hysron
Lutoral
Perlutex
Prodasone
Sodelut G
Veramix
Abbreviation:MPA
Chemical structure:
  • (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
  • 17-(acetyloxy)-6alpha-methylpregn-4-ene-3,20-dione
  • 17alpha-acetoxy-6alpha-methylprogesterone
  • 17-hydroxy-6alpha-methylpregn-4-ene-3,20-dione acetate
  • 6-alpha-methyl-17alpha-acetoxyprogesterone