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menogaril

A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin. Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin.

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US brand name:	Menogarol
Abbreviation:	7-OMEN MEN TUT-7
Code name:	U-52047
Chemical structure:	[2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha)]-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-9,16-dione 7-(R)-O-methylnogarol 7-con-O-methylnogarol 7-con-O-methylnorgarol
IND number:	22519
NSC code:	269148 8806

menogaril

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