methotrexate
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
| Synonym: | alpha-methopterin amethopterin methotrexate LPF methotrexate methylaminopterin methotrexatum metotrexato Rheumatrex |
|---|---|
| US brand name: | Jylamvo |
| Foreign brand name: | Brimexate Emtexate Emthexat Emthexate Farmitrexat Fauldexato Lantarel Ledertrexate Lumexon Maxtrex Medsatrexate Metex Methoblastin Metrotex Novatrex Texate Tremetex Trexeron Trixilem |
| Abbreviation: | MTX |
| Code name: | CL 14377 CL-14377 WR-19039 |
| Chemical structure: | 4-amino-10-methylfolic acid 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid |