microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138

A nanoparticle-based formulation containing an antagomir and oligonucleotide targeting microRNA-10b (miR-10b) encapsulated within a nanoparticle consisting of an iron oxide core that is coated with dextran, with potential antineoplastic activity. Upon administration of microRNA-10b antagomir-iron oxide/dextran-based nanoparticle TTX-MC138, the anti-miR-10b moiety targets and binds to miR-10b inside tumor cells. This inhibits miR-10b and kills miR-10b-overexpressing tumor cells. This may inhibit tumor progression and metastasis. miR-10b, a non-coding RNA that is highly expressed in a variety of metastatic tumor cells, plays a key role in tumor cell migration, invasion and metastasis. The dextran coated iron oxide nanoparticles allow for an increased half-life, decreased clearance and increased tumor cell uptake.