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midostaurin

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A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

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Synonym:	N-benzoyl-staurosporine N-benzoylstaurosporine
US brand name:	Rydapt
Code name:	CGP 41251 CGP41251 PKC 412 PKC412

midostaurin

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