mitoguazone
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.
| Synonym: | methylglyoxal bisguanylhydrazone mitoguazone dihydrochloride pyruvaldehyde bis(amidinohydrazone) |
|---|---|
| Foreign brand name: | Zyrkamine |
| Abbreviation: | MeGAG methyl-G methyl-GAG MGBG MGGH |
| Code name: | DRG-0223 NSC 32946 |
| Chemical structure: | 1,1'-[(methylethanediylidene)dinitrilo)diguanidine 2,2"-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide] methylglyoxal bis(amidinohydrazone) |
| IND number: | 927 |
| NSC code: | 32946 |