mitotane
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production.
| Synonym: | Chloditan Chlodithane Khloditan Mytotan o,p'-DDD Ortho,para-DDD |
|---|---|
| US brand name: | Lysodren |
| Foreign brand name: | Lisodren |
| Abbreviation: | DDD o,p' - DDD o,p'-DDD |
| Code name: | CB-313 WR-13045 |
| Chemical structure: | 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane 2,4'-dichlorodiphenyldichloroethane |
| NSC code: | 38721 |