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mitoxantrone hydrochloride

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The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
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Synonym:dihydroxyanthracenedione
dihydroxyanthracenedione dihydrochloride
mitoxantrone dihydrochloride
mitoxantrone HCl
mitoxantroni hydrochloridum
mitozantrone
mitozantrone hydrochloride
Foreign brand name:Mitroxone
Neotalem
Onkotrone
Pralifan
Abbreviation:DHAD
DHAQ
Code name:CL 232315
Chemical structure:1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione dihydrochloride
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone dihydrochloride
IND number:16802
NSC code:279836
301739
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