mitoxantrone hydrochloride
View Patient InformationThe hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
| Synonym: | dihydroxyanthracenedione dihydroxyanthracenedione dihydrochloride mitoxantrone dihydrochloride mitoxantrone HCl mitoxantroni hydrochloridum mitozantrone mitozantrone hydrochloride |
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| Foreign brand name: | Mitroxone Neotalem Onkotrone Pralifan |
| Abbreviation: | DHAD DHAQ |
| Code name: | CL 232315 |
| Chemical structure: | 1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione 1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione dihydrochloride 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone dihydrochloride |
| IND number: | 16802 |
| NSC code: | 279836 301739 |