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monophosphoryl lipid A

A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity. As a vaccine adjuvant, monophosphoryl lipid A (MPLA) stimulates both cellular and humoral responses to the vaccine antigen. Compared to LPS, MPLA exerts a similar immunostimulatory activity but with reduced toxicity.

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Abbreviation:	MPL MPLA
Chemical structure:	3-deacylated monophosphoryl lipid A 3-O-desacyl-4'-monophosphoryl lipid A

monophosphoryl lipid A

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