namodenoson
An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.
| Synonym: | A3AdR agonist CF102 adenosine receptor A3 agonist CF102 |
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| Abbreviation: | 2-Cl-IB-MECA C-Ibza-MU |
| Code name: | CF102 |
| Chemical structure: | 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide beta-D-ribofuranuronamide, 1-(2-Chloro-6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-1-deoxy-N-methyl- |