nanrilkefusp alfa
A human fusion protein consisting of the cytokine interleukin (IL)-15 and the high-affinity binding sushi+ domain of IL-15 receptor alpha (IL-15Ra), with potential antineoplastic activities. Upon administration, nanrilkefusp alfa activates and increases the levels of natural killer (NK) cells and memory CD8+ T cells. The memory T cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. Nanrilkefusp alfa is more potent than unmodified IL-15 and does not require endogenous IL-15Ra for its action.
| Synonym: | IL-15/IL-15 receptor alpha sushi+ domain fusion protein SO-C101 interleukin-15/interleukin-15 receptor alpha sushi+ domain fusion protein SO-C101 interleukin-15/interleukin-15 receptor alpha sushi+ domain fusion protein SOT101 |
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| Code name: | RLI 15 RLI-15 RLI15 SO C101 SO-C101 SOC101 SOT 101 SOT-101 SOT101 |