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naporafenib

An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, naporafenib binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival.

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Synonym:	pan-RAF inhibitor LXH254 pan-RAF kinase inhibitor LXH254 Raf family kinase inhibitor LXH254
Code name:	LXH 254 LXH-254 LXH254

naporafenib

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