nelarabine
View Patient InformationAn arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells.
US brand name: | Arranon |
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Code name: | 506U78 GW506U78 |
Chemical structure: | 2-amino-6-methoxypurine arabinoside 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine |
IND number: | 52611 |
NSC code: | 686673 |