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nucleoside analog DFP-10917

A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form, which functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.

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Synonym:	CNDAC
Code name:	DFP-10917
Chemical structure:	2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine

nucleoside analog DFP-10917

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