olaparib
View Patient InformationA small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.
| Synonym: | PARP inhibitor AZD2281 |
|---|---|
| US brand name: | Lynparza |
| Foreign brand name: | Olanib Olaparix |
| Code name: | AZD 2281 AZD-2281 AZD2281 KU-0059436 |