oleogel-S10

A topical gel formulation containing 10% birch tree bark (Betulae cortex) extract in 90% sunflower oil, with potential wound healing accelerating activities in various skin conditions, including epidermolysis bullosa (EB), partial thickness wounds and dermatitis. The birch bark extract is rich in the birch triterpene betulin and also contains lupeol, betulinic acid, erythrodiol and oleanolic acid. Upon topical administration of oleogel-S10 to the affected areas, the birch bark extract, containing mostly betulin, stimulates keratinocytes migration and differentiation into epithelial skin cells, thereby accelerating wound closure, skin restoration and wound healing. It also regulates the inflammatory response involved in wound healing, which further accelerates wound repair. This may decrease the wound healing process time and may reduce radiation dermatitis upon external beam radiation therapy.