Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

oncolytic adenovirus AdAPT-001

A replication competent human attenuated adenoviral vector, TAV-255, modified to express a human transforming growth factor beta (TGF-b) trap fusion protein that neutralizes TGF-b, with potential oncolytic, immunomodulating and antineoplastic activities. Upon administration, oncolytic adenovirus AdAPT-001 selectively binds to and replicates in tumor cells and induces tumor cell lysis. In addition, tumor cell lysis releases a variety of tumor-associated antigens (TAAs) which may potentially result in the activation of a systemic immune response against the TAAs-expresssing tumor cells. AdAPT-001 has been attenuated to prevent replication in healthy cells.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:oncolytic virus AdAPT-001
Code name:AdAPT 001
AdAPT-001
AdAPT001
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search