oncolytic adenoviris GM103

An oncolytic adenovirus, with potential antineoplastic and immunomodulating activities. Upon intratumoral administration of oncolytic adenovirus GM103, the oncolytic virus specifically infects and replicates in cancer cells without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells, thereby further killing tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune response, thereby inducing a cytotoxic T-lymphocyte (CTL)-mediated immune response and killing nearby non-infected tumor cells.