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pan-KRAS inhibitor PF-07934040

An orally bioavailable inhibitor of KRAS mutations, with potential antineoplastic activity. Upon oral administration, pan-KRAS inhibitor PF-07934040 targets, binds to and inhibits various forms of KRAS mutations, thereby inhibiting KRAS-dependent signaling. This inhibits the proliferation of and induces apoptosis in tumor cells in which KRAS is mutated. KRAS plays an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.
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Synonym:KRAS inhibitor PF-07934040
pan-KRAS mutant inhibitor PF-07934040
Code name:PF 07934040
PF 4040
PF-07934040
PF-4040
PF07934040
PF4040
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