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parsatuzumab

A humanized IgG1 monoclonal antibody directed against the epidermal growth factor-like domain multiple 7 (EGFL7) with potential antineoplastic activity. Parsatuzumab binds to EGFL7, thereby preventing the activities of EGFL7 on endothelial cells and inhibiting the survival and migration of endothelial cells during angiogenesis. EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types.

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Synonym:	anti-epidermal growth factor-like domain 7 monoclonal antibody MEGF0444A
Code name:	MEGF 0444A MEGF0444A RG 7414 RG7414

parsatuzumab

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