PCNA inhibitor AOH1996

An orally bioavailable, small molecule inhibitor of proliferating cell nuclear antigen (PCNA), with potential chemo-sensitizing and antineoplastic activities. Upon oral administration, PCNA inhibitor AOH1996 penetrates cells and targets and binds to PCNA, preventing the binding of PCNA's interacting proteins to PCNA. This disrupts the interactions between PCNA and these proteins and may result in DNA replication stress and inhibition of DNA repair, which may enhance the efficacy of some antineoplastic agents and induce apoptosis. PCNA is a scaffold protein involved in multiple cellular processes via its interactions with many proteins.