NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

PD-1 knockout autologous T lymphocytes
A population of engineered autologous T lymphocytes in which the gene encoding for the programmed cell death protein 1 (PDCD-1) is deleted, with potential immunomodulating activity. Following collection of peripheral blood lymphocytes and selection of T cells, the PDCD-1 gene was knocked out and the T cells were expanded. Upon reinfusion of the PDCD-1 knockout T lymphocytes, these T cells target and lyse cancer cells. The PDCD-1 protein, found on activated T cells and often overexpressed on T cells in cancer patients, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PDCD-1 knockout enhances cytotoxicity and T-cell-mediated anti-tumor immune responses. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:PD-1 knockout autologous T cells
PD-1-disrupted autologous T lymphocytes
PDCD1 gene knockout autologous T cells