penicillamine
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis.
| Synonym: | D-mercaptovaline D-Penicillamine Depamine |
|---|---|
| US brand name: | Cuprenil Cuprimine Depen Perdolat Sufortan |
| Foreign brand name: | Atamir Cupripen Distamine Kelatin Mercaptyl Metalcaptase Pendramine Trolovol |
| Chemical structure: | 3-mercapto-D-valine alpha-amino-beta-methyl-beta-mercaptobutyric acid beta-thiovaline beta,beta-dimethylcysteine |
| NSC code: | 81549 |