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peplomycin

A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity.

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Synonym:	pepleomycin
Abbreviation:	PEP
Chemical structure:	(S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide
NSC code:	276382

peplomycin

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