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phenobarbital

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.

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Abbreviation:	PHENO
Chemical structure:	5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
NSC code:	128143 9848

phenobarbital

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