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pirarubicin

An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
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Synonym:Tepirubicin
tetrahydropyranyl-doxorubicin
theprubicin
THP-Adriamycin
THP-doxorubicin
Foreign brand name:Pinorubicin
Theprubicine
Therarubicin
Abbreviation:THP-ADM
THP-DOX
Code name:1609-RB
1609RB
Chemical structure:(2"R)-4'-O-tetrahydropyranyladriamycin
(8S,10S)-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
[8S-[8alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
4'-O-tetrahydropyranyl doxorubicin
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