pirarubicin
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
| Synonym: | Tepirubicin tetrahydropyranyl-doxorubicin theprubicin THP-Adriamycin THP-doxorubicin |
|---|---|
| Foreign brand name: | Pinorubicin Theprubicine Therarubicin |
| Abbreviation: | THP-ADM THP-DOX |
| Code name: | 1609-RB 1609RB |
| Chemical structure: | (2"R)-4'-O-tetrahydropyranyladriamycin (8S,10S)-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione [8S-[8alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 4'-O-tetrahydropyranyl doxorubicin |