pixantrone dimaleate
The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.
| Synonym: | pixantrone maleate |
|---|---|
| Foreign brand name: | Pixuvri |
| Code name: | BBR 2778 |
| Chemical structure: | 6,9-bis((2-Aminoethyl)amino)benzo(g)Isoquinoline-5,10-dione (2z)-but-2-enedioate (1:2) benz(g)isoquinoline-5,10-dione, 6,9-bis((2-aminoethyl)amino)-, (2Z)-2-butenedioate (1:2) |