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plerixafor

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A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.
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US brand name:Mozobil
Code name:AMD 3100
JM-3100
LM-3100
SDZ SID 791
Chemical structure:1,1'-[1,4-phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
bis(tetraazacyclotetradecane) derivative
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