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plicamycin

An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption.

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Synonym:	aureolic acid mithramycin
US brand name:	Mithracin
Foreign brand name:	Mithracine
Abbreviation:	MTH
Code name:	A-2371 PA-144
IND number:	915
NSC code:	24559

plicamycin

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