Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

porcupine inhibitor XNW7201

An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, PORCN inhibitor XNW7201 targets, binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. PORCN, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers and plays a key role in cancer cell survival.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:PORCN inhibitor XNW7201
Code name:XNW 7201
XNW-7201
XNW7201
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search