porfiromycin
An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
| Synonym: | methyl mitomycin methyl mitomycin C Methylmitomycin porfiromycine porphyromycin |
|---|---|
| US brand name: | Promycin |
| Code name: | ENT-50825 U-14743 |
| Chemical structure: | [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione N-methylmitomycin C |
| IND number: | 1230 33509 |
| NSC code: | 56410 |