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porfiromycin

An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
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Synonym:methyl mitomycin
methyl mitomycin C
Methylmitomycin
porfiromycine
porphyromycin
US brand name:Promycin
Code name:ENT-50825
U-14743
Chemical structure:[1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
N-methylmitomycin C
IND number:1230
33509
NSC code:56410
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