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PRAME-targeting TCR-engineered NK cells

A preparation of natural killer (NK) cells that are engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME), with potential antineoplastic activity. Upon administration, the PRAME-targeting TCR-engineered NK cells specifically recognize and bind to PRAME expressed on cancer cells, thereby lysing the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types.

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Synonym:	engineered PRAME-TCR NKs PRAME-targeted TCR NK cells PRAME-TCR-NK cells PRAME-TCR-NKs

PRAME-targeting TCR-engineered NK cells

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