NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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preimplantation factor PIF-1
A synthetic version, known as PIF-1, of the peptide preimplantation factor (PIF), an embryo-secreted peptide, with potential activity against graft-versus-host disease (GVHD). PIF-1 is believed to have wide-ranging activity on the immunologic system, including a whole host of immunologic changes that resemble pregnancy, in which there is neither graft-versus-host or host-versus-graft disease between the mother and the embryo. Replication of the immunologic profile of pregnancy through the administration of PIF-1 may thus benefit patients undergoing bone marrow transplant (BMT) who experience graft-versus-host disease (GVHD). Native embryonic PIF has been found to have a multi-targeted effect on various aspects of the immune system, coordinated so that there is a successful embryonic implantation and a successful pregnancy. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:PIF-1 peptide
Abbreviation:PIF-1