Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

pritumumab

A naturally-produced human immunoglobulin G1 (IgG1) kappa antibody derived from a tumor-specific B-lymphocyte isolated from the regional draining lymph node of a patient with cervical carcinoma and targeted against the cell surface expressed vimentin, ecto-domain vimentin (EDV), with potential immunomodulating and antineoplastic activities. Upon administration, pritumumab targets and binds to EDV, which is expressed on a variety of tumor cell types but is not expressed by normal tissues and cells. This induces tumor cell death by antibody-dependent cell-mediated cytotoxicity (ADCC), and inhibits growth of EDV-expressing tumor cells. Pritumumab is able to penetrate the blood-brain barrier (BBB). Vimentin, an intracellular cytoskeletal protein, is overexpressed during epithelial-to-mesenchymal transition (EMT).
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:CLN-IgG
immunoglobulin G, anti-(human vimentin) (human monoclonal CLN G11 gamma1-chain), disulfide with human monoclonal CLN G11 kappa-chain, dimer
Code name:ACA-11
CLNH11
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search