Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

PSMA-specific targeting module TMpPSMA

A preparation of soluble adapter molecules consisting of an antigen-binding moiety targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), linked to a peptide motif recognizable by UniCAR02-T, that may be used to activate UniCAR02-T. Upon administration of PSMA-specific targeting module (TM) TMpPSMA, and upon co-administration of UniCAR02-T, the antigen-binding moiety of TMpPSMA targets and binds to cancer cells expressing PSMA, and the binding domain of UniCAR02-T binds to the nuclear antigen motif of TMpPSMA. This activates UniCAR02-T, and induces selective toxicity in and causes lysis of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:PSMA peptide target module TMpPSMA
PSMA-specific TM TMpPSMA
TMpPSMA
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search