PTTC topical ointment ACU-D1

A topical ointment formulation containing pentaerythritol tetrakis (3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate) (PTTC), an inhibitor of the 26S proteasome, with potential antiangiogenic and antineoplastic activities. Upon topical administration of the PTTC topical ointment ACU-D1, PTTC inhibits the activity of the 26S proteasome, blocking the targeted proteolysis normally performed by the proteasome and resulting in an accumulation of unwanted or misfolded proteins. This disrupts various cell signaling pathways and may lead to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.