Skip to main content

Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

R-1,3-butanediol-based supplement

A supplement composed of R-1,3-butanediol that may be used to increase the level of the ketone body beta-hydroxybutyrate (BHB), with potential protective and antineoplastic activities. Upon administration of R-1,3-butanediol-based supplement, R-1,3-butanediol is converted to BHB. BHB may activate the surface receptor hydroxycarboxylic acid receptor 2 (HCAR2) and induce the transcriptional regulator homeodomain-only protein (HOPX), thereby inhibiting cell proliferation in intestinal epithelial cells that express HCAR2 and HOPX.

Check for active clinical trials using this agent View this agent in the NCI Thesaurus

Synonym:	beta-hydroxybutyrate supplement R-1,3-butanediol supplement
US brand name:	Ketone-IQ

R-1,3-butanediol-based supplement

Search NCI's Drug Dictionary