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recombinant 70-kD heat-shock protein

A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response.

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Synonym:	70-kD Heat-Shock Protein Heat Shock Protein 70
Abbreviation:	HSP70

recombinant 70-kD heat-shock protein

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