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recombinant CD40-ligand

A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines.
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Synonym:CD154 antigen
gp39
T-BAM
T-cell antigen gp39
TNF-related activation protein
TRAP ligand
Abbreviation:CD40L
rhu CD40L
IND number:9593
NSC code:696600
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