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recombinant fowlpox-TRICOM vaccine

A cancer vaccine comprised of a recombinant fowlpox virus vector encoding TRICOM. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3) that may enhance antigen presentation and activate cytotoxic T-cells. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.
Synonym:rF-TRICOM (B7.1.iCAM1-LFA3-Fowlpox)
IND number:9710
9888
NSC code:710658
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