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rintodestrant

An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, rintodestrant specifically targets and binds to the estrogen receptor alpha (ERalpha; ERa; ESR1) and induces a conformational change that promotes ERalpha degradation and downregulation. This prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing cancer cells.

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Synonym:	selective estrogen receptor degrader G1T48 selective estrogen receptor downregulator G1T48
Code name:	G1T48 SERD G1T48

rintodestrant

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