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rubitecan

A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks.

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Synonym:	9-nitro-CPT 9-nitrocamptothecin nitrocamptothecin
US brand name:	Camptogen Orathecin
Abbreviation:	9-NC
Code name:	RFS 2000
Chemical structure:	9-nitro-20 (S-)camptothecin
NSC code:	603070

rubitecan

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