rubitecan
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks.
| Synonym: | 9-nitro-CPT 9-nitrocamptothecin nitrocamptothecin |
|---|---|
| US brand name: | Camptogen Orathecin |
| Abbreviation: | 9-NC |
| Code name: | RFS 2000 |
| Chemical structure: | 9-nitro-20 (S-)camptothecin |
| NSC code: | 603070 |