samarium Sm 153-DOTMP
A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.
| Synonym: | 153 Sm-DOTMP 153Sm-DOTMP Sm-153-DOTMP |
|---|---|
| US brand name: | CycloSam |
| Chemical structure: | Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic acid Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic acid |