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samarium Sm 153-DOTMP

A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.
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Synonym:153 Sm-DOTMP
153Sm-DOTMP
Sm-153-DOTMP
US brand name:CycloSam
Chemical structure:Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic acid
Sm-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic acid
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