sargramostim
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.
| Synonym: | 23-L-leucine colony-stimulating factor 2 colony stimulating factor 2 CSF-2 GM-CSF granulocyte macrophage colony-stimulating factor sargramostatin |
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| US brand name: | Leukine Prokine |
| Abbreviation: | GM CSF GM-CSF rhu GM-CFS |
| Code name: | DRG-0012 |