sarilumab
A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inflammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation.
| Synonym: | immunoglobulin G1, anti-human interleukin 6 receptor alpha) (human REGN88 heavy chain), disulfide with human REGN88 light chain, dimer |
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| US brand name: | Kevzara |
| Code name: | REGN88 SAR153191 |