Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

sarilumab

A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inflammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:immunoglobulin G1, anti-human interleukin 6 receptor alpha) (human REGN88 heavy chain), disulfide with human REGN88 light chain, dimer
US brand name:Kevzara
Code name:REGN88
SAR153191
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search