semustine
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity.
| Synonym: | CCNU, methyl- MCCNU methyl CCNU methyl-CCNU |
|---|---|
| Abbreviation: | MeCCNU |